wound infections. Which one of the following best describes the
mode of action of cefazolin?
(A) It acts as an electron sink depriving the bacteria of reducing
(B) It binds to the 30S ribosome and inhibits bacterial protein
(C) It inhibits transcription of bacterial mRNA.
(D) It inhibits transpeptidases needed to synthesize peptidoglycan.
(E) It inhibits folic acid synthesis needed to act as a methyl donor.
synthesis by blocking the production of tetrahydrofolic acid?
the following is the most accurate?
(A) Both act at the level of the cell wall.
(B) Both are bactericidal drugs.
(C) Both require an intact -lactam ring for their activity.
(D) Both should not be given to children under the age of 8 years
because damage to cartilage can occur.
(E) They should not be given together because they are
infections. Which one of the following is a combination in which
both drugs act to inhibit the same metabolic pathway?
(A) Amphotericin and flucytosine
(B) Isoniazid and rifampin
(C) Penicillin G and gentamicin
(D) Sulfonamide and trimethoprim
is the most accurate?
(A) Cleavage of the -lactam ring will inactivate penicillins but
(B) Penicillins act by inhibiting transpeptidases but cephalosporins
(C) Penicillins and cephalosporins are both bactericidal drugs.
(D) Penicillins and cephalosporins are active against gram-positive
cocci but not against gram-negative rods.
(E) Renal tubule damage is an important adverse effect caused by
both penicillins and cephalosporins.
synthesis in bacteria, which one of the following is the most accurate?
(A) Ciprofloxacin inhibits RNA polymerase by acting as a nucleic
(B) Rifampin inhibits the synthesis of messenger RNA.
(C) Sulfonamides inhibit DNA synthesis by chain termination of
the elongating strand.
(D) Trimethoprim inhibits DNA polymerase by preventing the
unwinding of double-stranded DNA.
following is the most accurate?
(A) Both classes of drugs are bactericidal.
(B) Both classes of drugs inhibit protein synthesis by binding to
the 30S ribosomal subunit.
(C) Both classes of drugs inhibit peptidyl transferase, the enzyme
that synthesizes the peptide bond.
(D) Both classes of drugs must be acetylated within human cells
to form the active antibacterial compound.
(E) Both classes of drugs cause brown staining of teeth when
administered to young children.
and itraconazole, is based on the presence in fungi of which one
of the following?
(A) 30S ribosomal subunit
(B) Dihydrofolate reductase
(C) DNA gyrase
(E) Mycolic acid
which are an important consideration when deciding
which antibiotic to prescribe. Which antibiotic causes significant
neurotoxicity and must be taken in conjunction with pyridoxine
(vitamin B6) to prevent these neurologic complications?
(rash when exposed to sunlight)?
(A) Amphotericin B