Chapter 38: DNA Nonenveloped Viruses

Chapter 38: DNA Nonenveloped Viruses

SELF-ASSESSMENT QUESTIONS

1. Regarding adenoviruses, which one of the following statements is

most accurate?

(A) Acyclovir is the drug of choice for life-threatening infections.

(B) They cause pharyngitis, pneumonia, and conjunctivitis (“pink

eye”).

(C) They are often transmitted across the placenta and cause

hydrocephalus in the fetus.

(D) The adenovirus vaccine is recommended for all children prior

to entering first grade.

(E) Laboratory diagnosis depends on seeing multinucleated giant

cells on biopsy as the virus has not been grown in cell culture.

1. Regarding human papillomavirus (HPV), which one of the following

statements is most accurate?

(A) There is no vaccine available against HPV.

(B) Acyclovir is effective in preventing lesions caused by HPV but

does not cure the latent state.

(C) Antigen–antibody complexes play an important role in the

pathogenesis of warts caused by HPV.

(D) The early proteins of HPV play a more important role in malignant

transformation than the late proteins.

(E) The diagnosis of HPV infection is usually made by detecting

cytoplasmic inclusions within giant cells in the lesions.

1. Regarding parvovirus B19, which one of the following statements

is most accurate?

(A) A vaccine is available that contains killed virus as the

immunogen.

(B) Patients infected by parvovirus B19 can be diagnosed in the

laboratory using the cold agglutinin test.

(C) Parvovirus B19 causes a severe anemia because it preferentially

infects erythrocyte precursors such as erythroblasts.

(D) It commonly infects neutrophils, resulting in an immunodeficiency

that predisposes to infections by pyogenic bacteria.

(E) Parvoviruses have a double-stranded DNA genome but require

a DNA polymerase in the virion because they replicate in the

cytoplasm.

1. A 24-year-old woman is seen by her gynecologist for a routine Pap

smear. The smear shows cervical intraepithelial neoplasia grade 3

(CIN 3). You decide to examine her long-term male sexual partner.

Which one of the following is the most likely finding?

(A) Condylomata lata

(B) Condylomata acuminata

(C) Penile intraepithelial neoplasia associated with HPV-6

(D) Penile intraepithelial neoplasia associated with HPV-16

ANSWERS

1. (B)
2. (D)
3. (C)
4. (D)