is preproinsuluin cleaved to proinsulin in the Golgi-apparatus?

is preproinsuluin cleaved to proinsulin in the Golgi-apparatus?

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Answer

• No.
  Preproinsuluin is cleaved to proinsulin in the Endoplasmic Reticulum
  Explanation:
  The ribosomes take the preproinsulin amino acid chain to the endoplasmic reticulum where the signal peptide is removed by the enzyme signal peptidase. This produces proinsulin which is then processed for maturity and conversion to the active insulin. There are several endopeptidase enzymes involved in converting proinsulin to insulin, which removes C peptide, thereby generating the mature form of insulin

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