One of Topamax side effects is metabolic acidosis. It happens due to the drug inhibiting the enzyme carbonic anhydrase. Which of the following are true about Topamax effects? It impairs the normal reabsorption of filtered HCO3− It generates an imbalance in the bicarbonate:carbonic acid buffer It stimulates the release of ketones into the bloodstream It generates an imbalance in the phosphate buffer

One of Topamax side effects is metabolic acidosis. It happens due to the drug inhibiting the enzyme carbonic anhydrase. Which of the following are true about Topamax effects?
It impairs the normal reabsorption of filtered HCO3−
It generates an imbalance in the bicarbonate:carbonic acid buffer
It stimulates the release of ketones into the bloodstream
It generates an imbalance in the phosphate buffer

Answer

• It generates an imbalance in the bicarbonate:carbonic acid buffer
  Explanation:
  CArbonic anhydrase aids in the conversion of carbon dioxide to carbonic acid and bicarbonate ions. The same enzyme converts bicarbonate ions back to carbon dioxide. This describes the carbonic acid-bicarbonate buffer system whereby introduction of a strong base causes its reaction with carbonic acid to form bicarbonate ions, which reduces a potential increase in pH. The drug inhibits the action of this buffer indirectly by inhibiting the action of enzyme carbonic anhydrase.