which of the following is the closest description of Phase II metabolism?
a- Hydrolysis of aspirin
b-reactions which add a large biomolecule to a functional group already present on a drug or one of it
c-Reduction reaction of a ketote functional group
d-Reduction of a ketone in a stomach
Answer
- b-reactions which add a large biomolecule to a functional group already present on a drug or one of it
Explanation:
In drug metabolism, there is both phase I and phase II reactions which occur in the liver and which are involved in clearing the drug from the system. phase I involves oxidation, reduction, or hydrolysis of the parent drug converting it to a more polar molecule. On the other hand, phase II metabolism involves addition or conjugation of the drug or its metabolites with another molecule through processes like glucuronidation, acylation among others.
